oxidative aromatization of some 1,4-dihydropyridines by aqueous hydrogen peroxide in ethanol
نویسندگان
چکیده
some 3, 5-diacyl or 3,5-diester 1,4-dihydropyridines were oxidized to the corresponding pyridine derivatives using hydrogen peroxide in aqueous ethanol in the presence of potassium bromide and acetic acid as the catalysts. the reaction was carried out in ethanol and products were isolated in high to excellent yields. however, oxidation of 3,5-diacetyl 1,4-dihydropyridines is slower than 3,5-diester 1,4-dihydropyridines under the same condition. furhermore, the reaction is facilitated by electron releasing groups on 4-substituent of dihydropyridine ring. the cheapness of reagent, high yielding, easy workup and mild condition makes this method a useful addition to the available method in organic synthesis. in addition, employment of clean oxidant h2o2 together with nontoxic solvent ethanol makes it friendly to the environment.
منابع مشابه
Oxidative aromatization of some 1,4-dihydropyridines by aqueous hydrogen peroxide in ethanol
Some 3, 5-diacyl or 3,5-diester 1,4-dihydropyridines were oxidized to the corresponding pyridine derivatives using hydrogen peroxide in aqueous ethanol in the presence of potassium bromide and acetic acid as the catalysts. The reaction was carried out in ethanol and products were isolated in high to excellent yields. However, oxidation of 3,5-diacetyl 1,4-dihydropyridines is slower than 3,5-die...
متن کاملProgesterone and Cilostazol Protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide
Abstract Reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. It has been shown that progesterone and cilostazol possess antioxidant properties. The present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...
متن کاملOxidative desulfurization of light fuel oil by using hydrogen peroxide in the presence of acetic acid catalyst
Hydrogen peroxide as an oxidant agent was used for desulfurization of a petroleum hydrocarbon fraction (C10-C22) with boiling range of 175-375 ℃, (light fuel oil) in the presence of acetic acid as catalyst. The oxidation was performed in an ultrasonic bath. It is found that increasing the amount of hydrogen peroxide lead to increase the oxidation rate and so desulfurizatio...
متن کاملEffects of mulberry ethanol extracts on hydrogen peroxide-induced oxidative stress in pancreatic β-cells.
Reactive oxygen species (ROS) are key mediators of mammalian cellular damage and are associated with diseases such as aging, arteriosclerosis, inflammation, rheumatoid arthritis and diabetes. Type 1 diabetes develops upon the destruction of pancreatic β-cells, which is partly due to ROS activity. In this study, we investigated the cytoprotective and anti-oxidative effects of fractionated mulber...
متن کاملOxidative aromatization of some 1,4-dihydropyridine derivatives using NaBrO3
In this study, oxidation of some 3,5-diacyl or 3,5-diester 1,4-dihydropyridines to corresponding pyridine derivatives using sodium bromate in the presence of NH4Cl, NaHSO4 and Bu4NHSO4 under thermal conditions has been investigated. The yield and structure of formed products is similar under all conditions; however, the reaction is accelerated in the presence of Bu4NHSO4 and NaHSO4. In addition...
متن کاملHydrogen peroxide removal by the calf aqueous outflow pathway.
Previous studies have shown that aqueous humor of calf and human eyes contains about 25 microM hydrogen peroxide. We have studied the removal of hydrogen peroxide by the outflow pathway of intact, freshly enucleated, calf eyes. Eyes were immersed under silicone oil that had a density greater than water and medium containing various agents was perfused into the anterior chamber. Medium passing t...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian chemical communicationناشر: payame noor university (pnu)
ISSN 2423-4958
دوره 3
شماره Issue 2, pp. 85-179 2015
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023